Table 1 Irritancy discrepancies
Perfume chemicals 1 to 10, 11 to 20, 21 to 30, 31 to 39
Perfume chemicals 11 to 21 of 39
| chemical | Good Scents | ChemIDPlus | EU/IUCLID | other |
|---|---|---|---|---|
| 11. Galaxolide | Main page (all forms): “irritant”; No MSDS for 100% concentration or 50% in bb. MSDS for 50% in dep or ipm: “irritating to skin”, skin and eye irritation “not determined” | Skin/eye irritant | IUCLID: moderately irritating per one rabbit skin irritation test; not irritating per others. EC classification “not irritating.” Rabbit eye irritation tests negative. | HERA: “neither an eye nor a skin irritant”. |
| 12. Dodecahydro3a, 6,6,9a-tetramethylnaphtho [2,1b] furan | No reference to irritancy | No reference to irritancy | ||
| 13a. ortho-anisaldehyde/2-anisaldehyde (CAS 135-02-4) | Irritant | Skin/eye irritant | ||
| 13b. ortho-anisaldehyde/4-anisaldehyde (CAS 123-11-5) | Irritant/irritating to skin and eyes. Moderate rabbit skin irritation; eye irritation “not determined”; human experience with 10% solution: “no irritation or sensitization.” | Skin/eye irritant | Per 1988-1995 Cornell MSDS “CAN BE HARMFUL IF INHALED, SWALLOWED AND ABSORBED THROUGH THE SKIN. CAN CAUSE EYE AND SKIN IRRITATION. DUST AND/OR VAPORS CAN CAUSE IRRITATION TO RESPIRATORY TRACT.” | |
| 14. Coumarin | Skin and eye irritation not determined | No reference to irritancy | ||
| 15. Cedrol | No reference to irritancy | No reference to irritancy | ||
| 16. Vanillin | Main page: no reference to irritancy; MSDS states “irritating to eyes” and skin and eye irritation “not determined” | No reference to irritancy | SIDS dossier: not irritating in humans | |
| 17. Exaltolide | Not determined; human experience 10% solution: “no irritation or sensitization.” | No reference to irritancy | ||
| 18. Tricyclodecenyl acetate Confusion over identity, overlap with flor acetate | 5413-60-5/2500-83-6: Main page no ref. to irritancy. MSDS says skin and eye irritation “not determined”; human experience: 8% solution: “no irritation or sensitization.” 64001-15-6 irritant per main page; no MSDS | 5413-60-5: Skin/eye irritant; no reference to irritancy for 2500-83-6 or 64001-15-6 | ||
| 19. Tricyclodecenyl propionate | No reference to irritancy | Skin/eye irritant | ||
| 20. Ethyl vanillin | No reference to irritancy on main page; MSDS states “irritating to eyes, respiratory system, and skin” Human skin irritation mild; eye irritation “not determined” | Skin/eye Irritant | Vermont Safety Information Resources, Inc: primary irritant. Acros MSDS: “Causes eye and skin irritation...Causes digestive and respiratory tract irritation. Light sensitive.” Cites mild human skin irritation. |